[Alexinator]

Mine is Dr Nefarious from the Ratchet and Clank series.

[Graystripe2000]

I have several:
King of Sorrow from Klonoa 2
The Shadow Blot from Epic Mickey (Fun fact: He originally, despite his name, looked like the Horned King in the game's early stages)
Red from Spyro: A Hero's Tail
Ripto (also from Spyro)
Cynder (Legend of Soyro: A New Beginning)
Dark Samus/ Metroid Prime (Metroid Prime trilogy)
Honorable mention goes to Lyric from Sonic Boom: Rise of Lyric/ Shattered Crystal

[Braixen]

Opera Kranz from Solatorobo
Best waifu 10/10

Also maybe GLaDOS and Wheatley from the Portal series

[Voka~Daemyn]

Ehh don't have any really.
But for the Klonoa games it's Ghadius.
Any other game I am just indecisive.

[BinaryPulsar]

Kuro -Ori And The Blind Forest-
K.O.S -do i really need to specify-
GANON -zelda?-
Octarians -splatoots-
Brevon -freedomy planety-
every villain in Undertale
Zeref. Fairy Tail isn't originally a game, but it has a game so it counts! (right?)
Risky Boots -Shantae-
(i may add more?)