Well, you can pixel art in any program really, doesn't really need to be like, a specific one, i, personally just use photoshop, to pixel art, all you really have to do is just, make the image resolution low, and, have like, palette for characters and stuff, well, most pixel arts don't really care about the palette part and just make it low res, now, since you said "how to break them into sprites", like, do you want to know how to implement these into some game or something? It would be a completely different story then.